MANUDB: database and application to retrieve and visualize mammalian NUMTs

TL;DR

MANUDB is a database that helps researchers find and visualize mitochondrial DNA fragments integrated into mammalian nuclear genomes.

Contribution

The novel contribution is the public release of MANUDB, a database and tool for retrieving and visualizing NUMTs in mammalian genomes.

Findings

MANUDB provides access to results from a computational pipeline for identifying NUMTs in mammalian genomes.

The database allows users to retrieve and visualize integrated mitochondrial DNA fragments in nuclear genomes.

MANUDB supports research in evolutionary biology, cancer, and genome analysis by making NUMT data publicly accessible.

Abstract

There is an ongoing genetic flow from the mitochondrial genome to the nuclear genome. The mitochondrial sequences that have integrated into the nuclear genome have been shown to be drivers of evolutionary processes and cancerous transformations. In addition to their fundamental biological importance, these sequences have significant consequences for genome assembly and phylogenetic and forensic analyses as well. Previously, our research group developed a computational pipeline that provides a uniform way of identifying these sequences in mammalian genomes. In this paper, we publish MANUDB—the MAmmalian NUclear mitochondrial sequences DataBase, which makes the results of our pipeline publicly accessible. With MANUDB one can retrieve and visualize mitochondrial genome fragments that have been integrated into the nuclear genome of mammalian species.

Database URL: manudb.streamlit.app

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