# Capecitabine-Induced Severe Refractory Diarrhoea Managed With Methylprednisolone: A Case Report

## TL;DR

A patient with severe, treatment-resistant diarrhea from capecitabine chemotherapy was successfully treated with methylprednisolone.

## Contribution

Demonstrates successful use of methylprednisolone for capecitabine-induced diarrhea, not previously recommended in guidelines.

## Key findings

- Steroids like methylprednisolone may be effective for severe, refractory capecitabine-induced diarrhea.
- Current guidelines do not include steroids for this condition, suggesting a potential treatment gap.

## Abstract

Chemotherapy-induced diarrhoea (CID) is a common adverse effect, especially with capecitabine. The majority of cases are mild. Current guidelines have recommended loperamide and octreotide for severe CID. Steroids have not been included in the current guidelines. We present a case of treatment-resistant capecitabine-induced diarrhoea, successfully managed with methylprednisolone.