# Atypical Guillain-Barré Syndrome in the Context of COVID-19: A Case Report

**Authors:** Cláudia Rodrigues Alves, Patrícia Simões, Bernardo Silva, Jessenia Chinchila, Luís Siopa

PMC · DOI: 10.7759/cureus.77791 · Cureus · 2025-01-21

## TL;DR

This paper reports a rare case of atypical Guillain-Barré Syndrome in a man infected with COVID-19, highlighting diagnostic challenges and the possible link between the virus and the condition.

## Contribution

The novelty lies in presenting a unique case of atypical GBS associated with SARS-CoV-2 infection, contributing to understanding of their potential connection.

## Key findings

- A 60-year-old man developed atypical Guillain-Barré Syndrome following a confirmed SARS-CoV-2 infection.
- The case highlights the diagnostic difficulties of atypical GBS presentations in the context of viral infections like COVID-19.

## Abstract

Guillain-Barré syndrome (GBS) is an acute, immune-mediated disease that can be potentially life-threatening. The classic presentation of GBS, characterized by the onset of progressive and ascending muscle weakness following an infectious process, is usually recognized promptly. However, atypical variants with unusual presentations may pose significant diagnostic challenges, resulting in delayed diagnosis and an increased likelihood of unfavorable outcomes. Emerging reports have explored potential associations between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and GBS, though the mechanisms underlying these connections remain uncertain. We present the case of a 60-year-old man diagnosed with an atypical form of GBS in the context of COVID-19 infection.

## Linked entities

- **Diseases:** Guillain-Barré syndrome (MONDO:0016218), COVID-19 (MONDO:0100096), severe acute respiratory syndrome coronavirus 2 (MONDO:0100096)

## Full-text entities

- **Diseases:** GBS (MESH:D020275), muscle weakness (MESH:D018908), COVID-19 (MESH:D000086382), -mediated (MESH:C567355)

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC11841962/full.md

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Source: https://tomesphere.com/paper/PMC11841962