# Information counselling during treatment with ototoxic medications for TB: a call to action

**Authors:** K. Khoza-Shangase, S.M. Arendse

PMC · DOI: 10.5588/pha.24.0053 · Public Health Action · 2025-03-01

## TL;DR

This paper highlights the need for better information counseling about hearing risks from aminoglycosides used in treating drug-resistant TB.

## Contribution

The paper emphasizes the critical role of audiologists in providing structured counseling for patients on ototoxic medications.

## Key findings

- Bedaquiline has reduced the use of ototoxic drugs in TB treatment.
- Aminoglycosides are still necessary for some XDR-TB patients.
- There is a lack of awareness about ototoxic effects in South Africa.

## Abstract

The introduction of bedaquiline (BDQ) has reduced the reliance on ototoxic drugs (e.g., aminoglycosides) for drug-resistant TB (DR-TB). This has significantly reduced ototoxic symptoms, such as tinnitus and dizziness, which often precede irreversible hearing loss. However, aminoglycosides remain essential for some extensively drug-resistant individuals with TB (XDR-TB) who are resistant to BDQ. In South Africa, there is a lack of adequate awareness of the potential ototoxic effects of aminoglycosides. The increasing prevalence of XDR-TB has, therefore, intensified the need for comprehensive information counselling. We call for a proactive role for audiologists in providing early, structured information counselling for these individuals.

## Linked entities

- **Chemicals:** bedaquiline (PubChem CID 5388906)
- **Diseases:** XDR-TB (MONDO:0100482)

## Full-text entities

- **Diseases:** DR-TB (MESH:D000069279), tinnitus (MESH:D014012), TB (MESH:D014390), ototoxic (MESH:D006311), dizziness (MESH:D004244), hearing loss (MESH:D034381), drug (MESH:D000081015), XDR-TB (MESH:D054908)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11841116/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC11841116/full.md

---
Source: https://tomesphere.com/paper/PMC11841116