# The ambition for a one-and-done vision-saving AAV vector

**Authors:** Therese Cronin

PMC · DOI: 10.1016/j.omtm.2025.101414 · Molecular Therapy. Methods & Clinical Development · 2025-02-03

## Full-text entities

- **Genes:** MIR142 (microRNA 142) [NCBI Gene 406934] {aka MIRN142, mir-142}, KDR (kinase insert domain receptor) [NCBI Gene 3791] {aka CD309, FLK1, VEGFR, VEGFR2}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, FLT1 (fms related receptor tyrosine kinase 1) [NCBI Gene 2321] {aka FLT, FLT-1, VEGFR-1, VEGFR1}
- **Diseases:** AMD (MESH:D006009), choroidal membrane rupture (MESH:D005322), retinal vein occlusion (MESH:D012170), retinal atrophy (MESH:D012173), CNV (MESH:D020256), age-related macular degeneration (MESH:D008268), diabetic retinopathy (MESH:D003930), blindness (MESH:D001766), proliferative eye diseases (MESH:D005128), diabetic macular edema (MESH:D008269), cancer (MESH:D009369), inflammatory (MESH:D007249), COVID-19 (MESH:D000086382), vision loss (MESH:D014786)
- **Chemicals:** NG101 (-), ranibizumab (MESH:D000069579)
- **Species:** Adeno-associated virus (species) [taxon 272636], Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Macaca (macaque, genus) [taxon 9539]

## Full text

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11840177/full.md

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Source: https://tomesphere.com/paper/PMC11840177