# Navigating neural pathways: how stimulation polarity shapes deep brain stimulation efficacy

**Authors:** Atefeh Asadi, Nabin Koirala, Muthuraman Muthuraman

PMC · DOI: 10.1093/braincomms/fcaf061 · Brain Communications · 2025-02-08

## TL;DR

This paper discusses how the polarity of electrical stimulation affects the effectiveness of deep brain stimulation in the subthalamic region.

## Contribution

It highlights new insights into how stimulation polarity influences neural pathway activation in deep brain stimulation.

## Key findings

- Stimulation polarity significantly impacts neural pathway activation in the subthalamic region.
- The findings suggest that adjusting stimulation polarity can improve the efficacy of deep brain stimulation treatments.

## Abstract

This scientific commentary refers to ‘Neural pathway activation in the subthalamic region depends on stimulation polarity’ by Borgheai et al. (https://doi.org/10.1093/braincomms/fcaf006).

## Full-text entities

- **Genes:** DRD2 (dopamine receptor D2) [NCBI Gene 1813] {aka D2DR, D2R}
- **Diseases:** neurodegeneration (MESH:D019636), hyperactive (MESH:D006948), Parkinson's disease (MESH:D010300), bradykinesia (MESH:D018476)
- **Chemicals:** dopamine (MESH:D004298)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11839837/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11839837/full.md

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Source: https://tomesphere.com/paper/PMC11839837