# Post‐COVID‐19 Neutropenia in an Infant With Thalassemia Minor: Case Report

**Authors:** Yasmine Elsherif, Omar Elsherif, Mehran Karimi, Ismail A. Ibrahim, Hana J. Abukhadijah

PMC · DOI: 10.1002/ccr3.9668 · Clinical Case Reports · 2025-02-19

## TL;DR

An infant with thalassemia minor developed severe neutropenia after a COVID-19 infection, highlighting the need for close monitoring of blood parameters in infants post-infection.

## Contribution

This case report highlights the rare occurrence of post-COVID-19 neutropenia in infants with thalassemia minor.

## Key findings

- An 11-month-old infant developed severe neutropenia following a COVID-19 infection.
- The case suggests a possible link between cytokine-induced suppression and hematopoietic dysfunction.
- Monitoring hematological parameters is crucial in infants post-COVID-19 to prevent complications.

## Abstract

This case of an 11‐month‐old female who developed severe neutropenia following COVID‐19 infection underscores the need for heightened vigilance and monitoring of hematological parameters in infants post‐COVID‐19. The exact mechanism of COVID‐19‐induced neutropenia is not fully understood, but it may involve cytokine‐induced suppression of hematopoiesis and bone marrow repression due to the inflammatory response. Given the potential for serious clinical implications, including increased susceptibility to infections, it is crucial to effectively identify and manage neutropenia in this vulnerable population. Further research is necessary to elucidate the underlying mechanisms and optimize treatment strategies for COVID‐19‐related hematological complications in infants.

## Linked entities

- **Diseases:** neutropenia (MONDO:0001475), thalassemia minor (MONDO:0044210), COVID-19 (MONDO:0100096)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** inflammatory (MESH:D007249), Post-COVID-19 Neutropenia (MESH:D000094024), COVID-19 (MESH:D000086382), neutropenia (MESH:D009503), Thalassemia (MESH:D013789), infections (MESH:D007239), hematological complications (MESH:D011250)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11839831/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11839831/full.md

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Source: https://tomesphere.com/paper/PMC11839831