# Cortical modulation of BOLD signals in white matter

## TL;DR

This study explores how brain cortex activity influences BOLD signals in white matter, revealing distinct spatial patterns and myelination correlations.

## Contribution

The study identifies network-specific spatial patterns and myelination correlations in white matter BOLD signals modulated by cortical activity.

## Key findings

- Cortical networks with basic functions contribute more to white matter BOLD fluctuations than higher-level networks.
- Each cortical network shows distinct spatial patterns in white matter projections.
- Myelination levels correlate strongly with white matter BOLD signal projections.

## Abstract

The relationship of BOLD signals in white matter to cortical neural activity remains unclear. We quantified the degree to which spontaneous neural activities in the cortex, which are reflected in low frequency fluctuations in cortical BOLD signals, modulate BOLD signals in white matter. From measurements of resting state correlations we find cortical networks of more basic level functions tend to contribute more to correlated fluctuations in white matter than those of higher level functions. In addition, each cortical network exhibits distinct, structurally interpretable spatial distribution patterns of white matter projections. Moreover, the myelination level of cortical networks is found to be strongly correlated with the white matter projection of cortical BOLD signals. Our findings confirm that BOLD signals in white matter encode neural activity in proportion to the spontaneous activity of individual cortical networks, and with network-specific spatial distribution patterns, which could be mediated by the microstructure of the brain cortex.