# Retraction: Titanium dioxide nanoparticles induce mitochondria-associated apoptosis in HepG2 cells

**Authors:** Zhenglin Xia, Jingliang He, Bowei Li, Ke He, Wenbing Yang, Xiaoxun Chen, Jinqian Zhang, Guoan Xiang

PMC · DOI: 10.1039/d5ra90014j · 2025-02-19

## TL;DR

This paper retracts a previous study about how titanium dioxide nanoparticles cause cell death in HepG2 liver cells.

## Contribution

The retraction highlights issues with the original study's findings and conclusions.

## Key findings

- The original paper's results are no longer considered reliable.
- The retraction advises against citing the original work.

## Abstract

Retraction of ‘Titanium dioxide nanoparticles induce mitochondria-associated apoptosis in HepG2 cells’ by Zhenglin Xia et al., RSC Adv., 2018, 8, 31764–31776, https://doi.org/10.1039/C8RA05132A.

## Full-text entities

- **Chemicals:** Titanium dioxide (MESH:C009495)
- **Cell lines:** HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027)

---
Source: https://tomesphere.com/paper/PMC11837257