# Comprehensive management application of sulodexide on proteinuria: 2 case reports

## TL;DR

This paper presents two case reports showing that sulodexide, a drug with multiple effects, can help reduce proteinuria in patients with chronic kidney disease.

## Contribution

The novelty lies in demonstrating sulodexide's effectiveness in managing proteinuria in two distinct chronic disease cases.

## Key findings

- Sulodexide addition to treatment regimens led to reduced urinary protein levels in both patients.
- Disease symptoms remained stable after sulodexide was incorporated into treatment plans.
- Sulodexide shows potential for comprehensive management of proteinuria in chronic kidney disease patients.

## Abstract

Proteinuria is an important sign of kidney function decline and one of the common clinical manifestations in patients with chronic kidney disease and diabetic kidney disease, which are often accompanied by a gradual decline in kidney function. Therefore, effective management of proteinuria is of great significance for delaying the progression of kidney disease and protecting kidney function. Sulodexide is a mixture of fast-moving heparin and dermatan sulfate with anticoagulant, thrombolytic, anticardiovascular, lipid-lowering, and renal-protective effects. It has potential application value in the comprehensive management of proteinuria. This study reported two different chronic disease cases to explore the comprehensive management application of sulodexide in patients with long-term poor proteinuria control. Case 1 is a 45 years-old male with type 2 diabetes mellitus and hypertension accompanied by persistent proteinuria and intermittent edema in both legs. Case 2 is a 52 years-old female with chronic nephritis and rheumatoid arthritis accompanied by persistent proteinuria and edema in both legs. Two patients showed a decrease in urinary protein levels and stable control of the remaining signs of disease after the addition of sulodexide to their comprehensive treatment regimens, indicating that sulodexide plays an important role in the comprehensive management of proteinuria.