# Metastatic Melanoma to Ovary and Advances in Metastatic Melanoma Treatment: A Case Report

**Authors:** Melissa Cantave, Anita H Chen, Aakriti R Carrubba, Matthew Robertson

PMC · DOI: 10.7759/cureus.77664 · Cureus · 2025-01-19

## TL;DR

This case report describes a rare instance of melanoma spreading to the ovary and highlights recent advances in treatment.

## Contribution

The paper adds a new case to the literature on rare melanoma metastasis to the ovary and discusses recent treatment advances.

## Key findings

- Melanoma metastasis to the ovary is rare and often difficult to diagnose.
- Surgical excision and advances in genetic testing and systemic therapy offer potential treatment options.
- The prognosis for patients with ovarian metastases from melanoma remains poor.

## Abstract

Metastatic lesions to the ovary from melanoma are very rare. There have been several published case reports over the years documenting melanoma metastasizing to the adnexa. Ovarian metastases may either be asymptomatic or present with pelvic pain. As with most adnexal masses, diagnosis can be challenging and depends on the quality of imaging. When present, the prognosis is very poor. Surgical excision can be offered for symptomatic management, confirmation or diagnosis, and for cytoreduction; however, advances in genetic testing and systemic therapy have shown promise in treating this disease. To add to the growing body of literature, we present a case of melanoma metastasizing to the ovary and will discuss the advances in systemic therapy as well as genetic testing for these patients.

## Linked entities

- **Diseases:** melanoma (MONDO:0005105)

## Full-text entities

- **Diseases:** Ovarian metastases (MESH:D010049), Ovary (MESH:D010051), Metastatic Melanoma (MESH:D008545), Metastatic lesions (MESH:D000092182), adnexal masses (MESH:D000291), pelvic pain (MESH:D017699)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11835604/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11835604/full.md

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Source: https://tomesphere.com/paper/PMC11835604