# Pilomatrixoma of the parotid region: A benign tumor mimicking metastatic cutaneous squamous cell carcinoma

**Authors:** Nikita Grieder, Marcella Pucci, Claudio De Vito, Yan Monnier, Nicolas Dulguerov, Maxime Mermod

PMC · DOI: 10.1016/j.radcr.2025.01.065 · Radiology Case Reports · 2025-02-01

## TL;DR

A 66-year-old woman's parotid mass was initially thought to be cancer but was later diagnosed as a benign pilomatrixoma, emphasizing the need for accurate diagnostic methods.

## Contribution

The paper presents a rare case where a benign tumor was misdiagnosed as cancer, highlighting the importance of precise diagnostic techniques.

## Key findings

- Initial assessments suggested squamous cell carcinoma, but final analysis confirmed a pilomatrixoma.
- Accurate radiological interpretation and FNA are crucial for distinguishing between benign and malignant tumors.
- Misdiagnosis can lead to unnecessary treatment, underscoring the need for careful evaluation.

## Abstract

Head and neck tumors in adults present a broad differential diagnosis, particularly when considering malignant neoplasms that require prompt diagnosis and intervention. We report the case of a 66-year-old woman with a progressively enlarging mass in the left parotid region. Initial assessments, including fine needle aspiration biopsy and imaging studies from outside institutions, suggested a diagnosis of squamous cell carcinoma. However, final histopathological analysis revealed that the mass was consistent with a pilomatrixoma. This case highlights the critical importance of meticulous radiological interpretation and the role of fine needle aspiration cytology (FNA) in accurately distinguishing between these 2 entities before initiating treatment.

## Linked entities

- **Diseases:** squamous cell carcinoma (MONDO:0005096), pilomatrixoma (MONDO:0007564)

## Full-text entities

- **Diseases:** Head and neck tumors (MESH:D006258), Pilomatrixoma (MESH:D018296), malignant neoplasms (MESH:D009369), cutaneous squamous cell carcinoma (MESH:D002294)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11835548/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11835548/full.md

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Source: https://tomesphere.com/paper/PMC11835548