# Epithelioid Hemangioendothelioma (EHE) Mimicking Mesothelioma: Case Presentation and Review

## TL;DR

A rare cancer called epithelioid hemangioendothelioma was mistaken for mesothelioma, highlighting the need for thorough testing and repeat biopsies for accurate diagnosis.

## Contribution

The paper presents a case where EHE was misdiagnosed as mesothelioma, emphasizing the value of repeat biopsies and next-generation sequencing in atypical malignancies.

## Key findings

- Pulmonary EHE in a 41-year-old female was initially misdiagnosed as mesothelioma.
- Repeat biopsies and next-generation sequencing were crucial for correct diagnosis.
- EHE's nonspecific imaging and overlapping pathology with other malignancies complicate early detection.

## Abstract

Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular sarcoma that can initially present with a myriad of symptoms anywhere in the body. Imaging findings are often nonspecific, and the pathology tends to have overlap with other malignancies. As a result, it can be quite difficult to suspect and diagnose EHE. We present a case of pulmonary EHE in a 41-year-old female with left pleural thickening and subclavian tumor thrombus who was initially misdiagnosed and treated as mesothelioma. This instance demonstrates the importance of maintaining a broad differential and the utilization of repeat biopsies and next-generation sequencing for questionable diagnoses of atypical malignancies.