Brief biology and pathophysiology of Tekt bundles
Jun Yin, Min Liu, Xiao Wang, Hongming Miao, Wenjuan He, Wei Liu, Zhongying Yu, Qinghua Zhang, Jialian Bai, Yimei Cheng, Bing Ni
TL;DR
Tektins are essential proteins for cilia and flagella function, and their malfunction is linked to various diseases.
Contribution
This review compiles recent insights into Tektin functions and their regulation in health and disease.
Findings
Tektins stabilize microtubules in cilia and flagella.
Loss of Tekt1–5 leads to motility defects and diseases like infertility and retinal degeneration.
Tektin expression is regulated by multiple molecular mechanisms.
Abstract
Tektins, a family of microtubule-stabilizing proteins, are critical for cilia and flagella assembly in mammals. They maintain doublet microtubule stability and ciliary/flagellar motility. Loss of Tekt1–5 causes microtubule instability, impaired motility, and diseases like infertility, retinal degeneration, Mainzer-Saldino syndrome, and diabetic nephropathy. Pathophysiological stimuli regulate Tektin expression through transcriptional, posttranscriptional, translational, and posttranslational modifications. This review summarizes the latest findings on Tektin functions and their role in diseases.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsGenetic and Kidney Cyst Diseases · Fetal and Pediatric Neurological Disorders · Hedgehog Signaling Pathway Studies