“Friends or foes”: a new perspective of tumour metabolic transcriptional modification

TL;DR

The paper introduces a new perspective on how tumor metabolism influences cancer progression through transcriptional regulation.

Contribution

It proposes a comprehensive network linking tumor metabolism and transcriptional modifications to guide treatment strategies.

Findings

Metabolic transcriptional factors form a complex interactive network in tumors.

Transcriptional regulation can act synergistically or antagonistically in tumor metabolism.

There is heterogeneity in tumor metabolic transcriptional function.

Abstract

Energy metabolism plays a pivotal role in cancer clinical treatment and has become an important means of clinical diagnosis of tumour progression. However, current research mostly focuses on changes in metabolic products and neglects the deeper mechanisms of transcriptional regulation. This paper proposes a new perspective, establishing a comprehensive network that reveals the interaction between metabolism and transcription, which explores how tumour metabolism affects tumour progression through transcriptional modifications, and provides a novel approach for optimizing tumour treatment strategies. This viewpoint is conducive to overcoming current bottlenecks in treatment and promoting the development of drug combinations and personalized medicine.

Metabolic transcriptional factors form a complex interactive network in tumour.There is heterogeneity in tumour metabolic transcriptional function.Transcriptional regulation can act synergistically or antagonistically, rather than independently.

Metabolic transcriptional factors form a complex interactive network in tumour.

There is heterogeneity in tumour metabolic transcriptional function.

Transcriptional regulation can act synergistically or antagonistically, rather than independently.

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