Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system
Li Zhou, Chenchen Song, Hu Yang, Lianlian Zhao, Xianglei Li, Xiuping Sun, Kai Gao, Jianguo Guo
TL;DR
This study explores how simulated microgravity affects mice's behavior and brain function, revealing changes in activity, memory, and metabolism.
Contribution
The study introduces a 3D clinostat model that closely mimics spaceflight effects on the central nervous system in mice.
Findings
Clinostat-treated mice showed decreased activity and altered gait.
Brain transcriptome changes indicated immune and endocrine system involvement.
Serum metabolomics and gut microbiota showed altered metabolic pathways.
Abstract
A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous system. Eighteen mice were divided into three groups: control, survival box, and clinostat + survival box. Behavioral tests, femur micro-CT, brain transcriptomics, serum metabolomics, and fecal microbiomics were performed. Results showed decreased activity, altered gait, enhanced fear memory, bone loss, immune/endocrine changes in brain transcriptome, and altered metabolic pathways in serum and gut microbiota in clinostat-treated mice. The model closely mimics spaceflight-induced transcriptome changes, suggesting its value in studying microgravity-related neurological alterations and highlighting the need for attention to emotional changes in space.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsSpaceflight effects on biology · High Altitude and Hypoxia · Anesthesia and Neurotoxicity Research