# Diagnostic utility of p16 immunocytochemistry for Trichomonas in urine cytology

**Authors:** Liron Pantanowitz, Q Jackie Cao, Robert A Goulart, Christopher N Otis

PMC · DOI: 10.1186/1742-6413-2-11 · 2005-06-29

## TL;DR

This paper shows how p16 immunocytochemistry can help diagnose Trichomonas in urine samples, even in unexpected cases.

## Contribution

The study introduces p16 immunocytochemistry as a novel diagnostic tool for Trichomonas in non-typical clinical scenarios.

## Key findings

- p16 immunocytochemistry successfully identified Trichomonas in a male patient's urine sample.
- The method is recommended for use when trichomonads are suspected in unusual specimen types or patients.

## Abstract

We present a case in which p16 immunocytochemistry helped establish the diagnosis of Trichomonas in urine from a male patient. Based on this finding, we recommend p16 immunocytochemistry as a diagnostic tool for unexpected patients or specimen types in which potential trichomonads are identified following routine cytologic evaluation.

## Linked entities

- **Proteins:** CDKN2A (cyclin dependent kinase inhibitor 2A)

## Full-text entities

- **Genes:** CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}
- **Diseases:** Trichomonas infection (MESH:D014245), urethritis (MESH:D014526), diabetes (MESH:D003920), prostatitis (MESH:D011472), hematuria (MESH:D006417), HPV-infected (MESH:D030361), dysplasia (MESH:D015792), urethral strictures (MESH:D014525), sexually transmitted disease (MESH:D012749), inflammatory (MESH:D007249)
- **Chemicals:** metronidazole (MESH:D008795), Papanicolaou (-)
- **Species:** Trichomonas vaginalis (species) [taxon 5722], Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090], Trichomonas (genus) [taxon 5721]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC1183263/full.md

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Source: https://tomesphere.com/paper/PMC1183263