# Role of Adjuvant Radiotherapy in Sweat Gland Carcinoma: A Case Report and Literature Review

## TL;DR

This paper discusses a case of sweat gland carcinoma and reviews the potential benefits of adjuvant radiotherapy in managing this rare and aggressive skin cancer.

## Contribution

The paper presents a case report and literature review highlighting the possible role of adjuvant radiotherapy in sweat gland carcinoma.

## Key findings

- Adjuvant radiotherapy may improve local and regional control in sweat gland carcinoma with high-risk features.
- Diagnosis of sweat gland carcinoma is challenging due to clinical and histopathological variability.
- There is a lack of consensus guidelines for adjuvant treatment of sweat gland carcinoma.

## Abstract

Sweat gland carcinoma (SGC) is a rare type of malignant adnexal tumours of the skin (MATS). It has potential for local infiltration, regional nodal involvement, and distant metastasis. Wide local excision with regional lymph nodal dissection is the mainstay of treatment and there are no consensus guidelines for adjuvant treatment. We present a case report of a gentleman, suffering from SGC in the left lumbar region with axillary nodal metastasis, presenting with a longstanding skin nodule, with recent spurt in growth and ulceration over it. He was treated with wide local excision of the lesion and left axillary nodal dissection. Postoperative histopathology and immunohistochemistry confirmed the diagnosis of SGC. He received adjuvant radiotherapy to primary and nodal sites due to the presence of high-risk features. Diagnosis of SGC is very challenging due to clinical variation, nonspecific immunohistochemistry profile, and histopathological surprises. Due to the paucity of relevant literature, the role of adjuvant radiotherapy is still not established, but in view of the aggressive behaviour of SGC, radiotherapy significantly improves local and regional control, particularly in the presence of high-risk pathological features. Further studies in the domain of adjuvant treatment of SGC is needed to improve disease outcomes optimally.