# The regulation of triglyceride storage by Acsx4 and Acsx5 in Drosophila fat tissue

## TL;DR

This study explores how two genes, Acsx4 and Acsx5, regulate triglyceride levels in fruit fly fat tissue.

## Contribution

The study identifies Acsx4 and Acsx5 as regulators of lipid metabolism in Drosophila adipose tissue.

## Key findings

- Reducing Acsx4 and Acsx5 in fly fat tissue leads to increased triglyceride accumulation.
- Acsx4 and Acsx5 may regulate lipid breakdown, compensating for triglyceride buildup when 9G8 is reduced.
- 9G8 downregulation in adipose tissue upregulates Acsx4 and Acsx5.

## Abstract

The production of energy is one of the most fundamental requirements for organismal survival. Decreasing expression of
Drosophila
9G8
, an mRNA splicing protein, specifically in adipose tissue results in triglyceride accumulation. Decreasing
9G8
in adipose also results in upregulation of the acyl-CoA synthetases
Acsx4
and
Acsx5
; however, the functions of these genes in regulating lipid metabolism is not fully understood. Here, we decreased
Acsx4
and
Acsx5
in fly adipose tissue and this resulted in high triglycerides. This suggests that these genes regulate lipid breakdown, and their upregulation is perhaps compensating for the triglyceride accumulation observed when
9G8
levels are decreased.