# Oral manifestations of syphilis: A report of six cases

**Authors:** Manoela Wisniewski Bevervanso, Vanessa Carvajal Soto, Larissa Knysak Ranthum, Helen Heloene Rosa, Eduardo Bauml Campagnoli, Marcelo Carlos Bortoluzzi

PMC · DOI: 10.4317/jced.62248 · Journal of Clinical and Experimental Dentistry · 2025-01-01

## TL;DR

This paper reports six cases of syphilis with oral symptoms, highlighting common signs like ulcers and sores in the mouth.

## Contribution

The study provides a detailed clinical overview of oral syphilis cases diagnosed in a dental setting.

## Key findings

- Oral syphilis commonly affects the tongue, gingiva, and palates with mucous plaques and ulcers.
- Symptoms lasted between 3 weeks to 3 months, with painful sores and swollen lymph nodes being common.
- All six cases were confirmed as secondary syphilis through serological testing.

## Abstract

Syphilis is a highly contagious infectious disease primarily transmitted through sexual contact, caused by Treponema pallidum, an anaerobic gram-negative bacterium. Oral manifestations are significant, with the oral cavity often being the first site to exhibit symptoms. This study aims to present the clinical manifestations of oral syphilis through a six cases diagnosed in a dental setting. The results reveal that oral syphilis lesions predominantly affect areas such as the tongue, gingiva, and palates, presenting as mucous plaques, ulcerations, and erythematous regions. Painful oral sores and cervical lymphadenopathy were common, with symptoms varying in duration from 3 weeks to 3 months. All cases were classified as secondary syphilis and were confirmed through serological tests.

Key words:Syphilis, Treponema pallidum, Oral Cavity, Oral manifestation.

## Linked entities

- **Diseases:** syphilis (MONDO:0005976)
- **Species:** Treponema pallidum (taxon 160)

## Full-text entities

- **Diseases:** Syphilis (MESH:D013587), infectious disease (MESH:D003141), Painful oral sores (MESH:D010146), oral syphilis lesions (MESH:D009059), cervical lymphadenopathy (MESH:D002575), secondary syphilis (MESH:C536773)
- **Species:** Treponema pallidum (species) [taxon 160]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11829718/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11829718/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC11829718/full.md

---
Source: https://tomesphere.com/paper/PMC11829718