# Plasma Amino Acid Profiles and Clinical Outcome in Patients with Traumatic Brain Injury: A Study Protocol

## TL;DR

This study aims to analyze how plasma amino acid levels in traumatic brain injury patients relate to their clinical outcomes over time.

## Contribution

The study introduces a longitudinal approach to assess amino acid profiles and their correlation with TBI recovery metrics.

## Key findings

- Plasma amino acid concentrations will be measured at multiple time points in TBI patients.
- Clinical outcome parameters like APACHE II and SOFA scores will be correlated with amino acid levels.
- Results may guide future treatment strategies involving amino acid supplementation for TBI.

## Abstract

Background: The most common cause of cognitive and behavioral impairments,
disability, and mortality around the world is traumatic brain injury (TBI). The
imbalance between cerebral metabolism and inflammation leads to protein
breakdown and induces altered concentrations of serum amino acids, which can
serve as a diagnostic and prognostic sign in patients with TBI. This study aimed
to examine the alterations in plasma amino acid concentrations and their
relation to clinical outcomes in patients with TBIs.Materials and Methods: At
completion, this study will assess 107 patients suffering from TBI aged 18 to
65. Plasma amino acid concentrations, anthropometric indices, and clinical
outcome parameters including Acute Physiology and Chronic Health Evaluation
(APACHE) II, Sequential Organ Failure Assessment (SOFA), Nutrition Risk in the
Critically ill (Nutric) score, Glasgow coma scale (GCS), Intensive Care Unit
(ICU) discharge time, mechanical ventilator duration, and mortality rate will be
assessed at the beginning of the study, day 7, and day 14.Conclusion: This
longitudinal study will provide evidence for further clinical trials and
observational studies on amino acid supplementation and TBI. The results of this
study could inform future treatment strategies for TBI patients.