# A Young Adult With Persistent Headache: A Case of Central Neurocytoma

**Authors:** Mohammed A Johar, Amal R Dhaif, Alaa K Mahdi, Shaimaa H Banaji, Anas Ahmed

PMC · DOI: 10.7759/cureus.77470 · Cureus · 2025-01-15

## TL;DR

A 23-year-old man with a persistent headache was diagnosed with a central neurocytoma, a rare brain tumor, and successfully treated with surgery.

## Contribution

This case highlights the clinical presentation, diagnosis, and successful surgical management of a central neurocytoma in a young adult.

## Key findings

- The patient's symptoms and imaging led to the diagnosis of a central neurocytoma in the lateral ventricle.
- Complete surgical resection resulted in full recovery with no recurrence at six months.
- Early diagnosis and treatment are critical for favorable outcomes in central neurocytoma cases.

## Abstract

Central neurocytomas are rare, typically benign neuronal tumors that primarily affect young adults and are most commonly located within the lateral ventricles. This report presents the case of a 23-year-old male who presented with a two-month history of progressive headache, nausea, vomiting, and cognitive decline. Neurological examination revealed papilledema, indicative of increased intracranial pressure. Magnetic resonance imaging of the brain demonstrated a well-defined, partially calcified intraventricular lesion with associated obstructive hydrocephalus. Histopathological analysis following a stereotactic biopsy confirmed the diagnosis of central neurocytoma, with immunohistochemistry showing positivity for synaptophysin and neuronal nuclear antigen. The patient underwent a successful gross total resection of the tumor, and postoperative magnetic resonance imaging confirmed complete removal with no residual disease. The patient’s recovery was uneventful, and he remains asymptomatic at six months post-surgery with no evidence of recurrence. This case underscores the importance of early recognition, accurate diagnosis, and timely surgical intervention in the management of central neurocytomas. Additionally, it highlights the favorable prognosis associated with gross total resection, although long-term surveillance remains essential to detect any recurrence.

## Linked entities

- **Diseases:** central neurocytoma (MONDO:0019134)

## Full-text entities

- **Genes:** SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}
- **Diseases:** increased intracranial pressure (MESH:D019586), Central Neurocytoma (MESH:D018306), papilledema (MESH:D010211), vomiting (MESH:D014839), benign neuronal tumors (MESH:D009369), cognitive decline (MESH:D003072), intraventricular lesion (MESH:D006345), nausea (MESH:D009325), obstructive hydrocephalus (MESH:D006849), Headache (MESH:D006261)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11827534/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11827534/full.md

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Source: https://tomesphere.com/paper/PMC11827534