# Hiding in Plain Sight—Relapsing Polychondritis Disguised as Hip Arthritis: A Case Report and Literature Review

**Authors:** Zhanxia Li, Tao Ren

PMC · DOI: 10.1002/iid3.70159 · Immunity, Inflammation and Disease · 2025-02-14

## TL;DR

A case of relapsing polychondritis was initially misdiagnosed as hip arthritis, highlighting the need for better awareness of rare autoimmune conditions.

## Contribution

This case report highlights an atypical presentation of relapsing polychondritis and emphasizes the importance of multidisciplinary diagnosis.

## Key findings

- Relapsing polychondritis was misdiagnosed as hip osteoarthritis due to atypical symptoms.
- Multidisciplinary evaluation confirmed RP with tracheal stenosis and iritis.
- Corticosteroid therapy led to significant clinical improvement.

## Abstract

Relapsing polychondritis (RP) is a rare autoimmune disorder characterized by episodic inflammation of cartilaginous tissues. Its diverse clinical manifestations frequently pose diagnostic challenges and lead to misdiagnosis.

We present a 59‐year‐old female initially diagnosed with refractory hip osteoarthritis based on persistent left hip pain unresponsive to conventional anti‐inflammatory therapy. Subsequent development of stridor and dyspnea prompted comprehensive evaluation, including laryngotracheal imaging, autoimmune serology, and multidisciplinary consultation. Diagnostic criteria for RP were applied in accordance with revised Michet criteria.

Tracheal stenosis secondary to tracheal chondritis and iritis were identified, confirming the diagnosis of RP. Following initiation of corticosteroid therapy, the patient exhibited marked clinical improvement.

This case underscores the importance of enhanced clinical awareness regarding atypical presentations of RP, particularly when accompanied by evolving systemic symptoms. A multidisciplinary diagnostic approach is advocated to facilitate early detection and improve patient outcomes.

This article presents an unusual manifestation of relapsing polychondritis (RP), initially misdiagnosed as hip osteoarthritis. It underscores the importance of recognizing atypical presentations of RP and advocates for a multidisciplinary diagnostic approach to improve early detection and patient outcomes.

## Linked entities

- **Diseases:** relapsing polychondritis (MONDO:0019125), hip osteoarthritis (MONDO:0006629), tracheal stenosis (MONDO:0002568), iritis (MONDO:0006814)

## Full-text entities

- **Diseases:** Tracheal stenosis (MESH:D014135), dyspnea (MESH:D004417), RP (MESH:D011081), hip pain (MESH:D010146), iritis (MESH:D007500), autoimmune (MESH:D001327), inflammation (MESH:D007249), tracheal chondritis (MESH:D014133), hip osteoarthritis (MESH:D015207), Hip Arthritis (MESH:D001168), stridor (MESH:D012135)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC11826323/full.md

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Source: https://tomesphere.com/paper/PMC11826323