# Unexpected Increase in Bone Mineral Density With Rapamycin and Low-Dose Naltrexone: A Case Report of a 52-Year-Old Woman With Osteopenia

## TL;DR

A 52-year-old woman with low bone density saw a significant increase in bone strength after taking two low-dose drugs in a clinical trial.

## Contribution

Reports a novel case of increased bone density using rapamycin and low-dose naltrexone in an osteopenic patient.

## Key findings

- The patient experienced a 15.9% increase in lumbar spine BMD over two years.
- The treatment involved low-dose rapamycin and low-dose naltrexone.
- This case suggests potential new strategies for improving bone density in aging populations.

## Abstract

Osteopenia and osteoporosis are prevalent bone disorders characterized by reduced bone mineral density (BMD), leading to an increased risk of fractures. This case report presents a 52-year-old Caucasian female patient with osteopenia who experienced an unexpected 15.9% increase in lumbar spine BMD within two years after enrolling in a clinical trial involving low-dose rapamycin and subsequently starting low-dose naltrexone. This case potentially opens novel treatment strategies for bone density improvement in aging populations.