# Idiopathic Atrophoderma of Pasini and Pierini: Response to Mycophenolic Acid Treatment

## TL;DR

A patient with a rare skin condition called Atrophoderma of Pasini and Pierini showed improvement after being treated with mycophenolic acid, a finding not previously reported.

## Contribution

This is the first reported case of successful treatment of Atrophoderma of Pasini and Pierini using mycophenolic acid.

## Key findings

- A patient with a 19-year history of APP showed favorable response to mycophenolic acid treatment.
- No prior published reports describe the use of mycophenolic acid for treating APP.
- The case highlights the potential of mycophenolic acid as a novel therapeutic option for this rare condition.

## Abstract

Atrophoderma of Pasini and Pierini (APP) is a rare skin condition of unknown etiology. It is characterized by dermal atrophy with single or multiple hyperpigmented, non-indurated, and slightly depressed plaques on the trunk or limbs; unlike morphea, this condition does not cause induration.

In this report, we analyze the case of a patient diagnosed with APP with a 19-year history of progression, aiming to highlight the few cases published in the literature. The patient responded favorably to treatment with mycophenolic acid (MPA).

Therapeutic approaches for this condition are controversial due to its long-term progression and low frequency. Currently, there are no published reports on the use of MPA for the treatment of this condition.