# Global Trends in Research of Amino Acid Metabolism in T Lymphocytes in Recent 15 Years: A Bibliometric Analysis

**Authors:** Jiaona Xu, Yinan Yu, Shijie Li, Fanghui Qiu

PMC · DOI: 10.1155/jimr/3393342 · Journal of Immunology Research · 2025-01-25

## TL;DR

This paper analyzes global research trends on amino acid metabolism in T lymphocytes over the past 15 years using bibliometric methods.

## Contribution

The study provides a comprehensive bibliometric analysis of amino acid metabolism in T cells, highlighting research trends and key areas of focus.

## Key findings

- Research on amino acid metabolism in T cells has increased steadily over the past 15 years.
- The USA leads in both quantity and influence of research in this field.
- Recent studies emphasize the role of amino acid metabolism in regulatory T cells and CD8+ T cells.

## Abstract

Amino acid metabolism in T cells determines the therapeutic efficacy of T-cell-targeting drugs. To assess the direction of amino acid metabolism in T cells and construct related knowledge structure, we performed a bibliometric analysis aiming at amino acid metabolism in T cells utilizing studies publicized in recent 15 years. Three hundred thirty-seven related studies were downloaded from the Web of Science Core Collection (WoSCC), and the information on countries, institutes, and authors was collected and analyzed. In addition, the present research status and future trends were explored according to the results yielded from the analysis of cited references and keywords. This study revealed that publications regarding amino acid metabolism in T cells gradually increased each year. The USA is the top producer and most influential country in this field. Recent research has focused on the correlation between the metabolism of several amino acids and regulatory T cells (Tregs) and CD8+ T cells. Overall, this research offers a comprehensive exhibition on the field of amino acid metabolism in T cells, which will help researchers to study this domain more effectively and intuitively.

## Full-text entities

- **Chemicals:** Amino Acid (MESH:D000596)

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11824865/full.md

## References

87 references — full list in the complete paper: https://tomesphere.com/paper/PMC11824865/full.md

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Source: https://tomesphere.com/paper/PMC11824865