# Arrested Puberty in a Young Adult With a Macroprolactinoma: Case Report and Literature Review

## TL;DR

A 23-year-old man experienced arrested puberty due to a large prolactinoma, highlighting the impact of pituitary tumors on sexual development.

## Contribution

This case report adds to the limited literature on macroprolactinomas causing arrested puberty in young adults.

## Key findings

- A 23-year-old male presented with arrested puberty due to a macroprolactinoma.
- Hyperprolactinemia caused hypogonadotropic hypogonadism, affecting puberty development.
- The case emphasizes the importance of early diagnosis and treatment in young adults with pituitary tumors.

## Abstract

Prolactinoma is the most common pituitary tumor, with clinical presentations varying according to sex, age of onset, tumor size, and prolactin (PRL) levels. These tumors are rare in the pediatric and adolescent populations. Hyperprolactinemia leads to hypogonadotropic hypogonadism, resulting in reproductive, metabolic, sexual, and skeletal consequences that can affect puberty development. Here, we present the case of a 23-year-old male patient diagnosed with arrested puberty secondary to a macroprolactinoma. The clinical presentation, diagnostic approach, therapeutic management, and a literature review are discussed.