# Synthesis of a Hydroxy-15-Azasterol

## TL;DR

This paper describes the synthesis of a new compound, hydroxy-15-azasterol, which may help treat Niemann-Pick type C disease by mimicking cholesterol.

## Contribution

A convergent 12-step synthesis of hydroxy-15-azasterol from 2-oxepanone is reported for potential NPC treatment.

## Key findings

- A hydroxy-15-azasterol was successfully synthesized in 12 steps.
- The compound is a cholesterol mimic that binds to NPC1 and NPC2 proteins.

## Abstract

Niemann-Pick type
C (NPC) is a lysosomal storage disorder that
will cause eventual brain damage with limited treatment options available.
Though clinical trials are undergoing with repurposed pharmaceuticals,
no novel chemotype exists purely for the treatment of NPC. In 2021,
an azasterol was found to bind to both NPC1 and NPC2 proteins and
is considered as a cholesterol mimic. A convergent synthesis to obtain
a hydroxy-15-azasterol was completed in 12 steps, from 2-oxepanone.