# Achieving Response With Bolus Dosing of Valproate in Electroconvulsive Therapy (ECT)-Induced Mania: A Case Report

**Authors:** Venkatesh Sreeram, Nana Bonsu

PMC · DOI: 10.7759/cureus.77395 · Cureus · 2025-01-13

## TL;DR

This case report shows how giving valproate during ECT sessions helped manage mania symptoms in a patient.

## Contribution

The report introduces the novel use of valproate bolus dosing during ECT to manage ECT-induced mania.

## Key findings

- Bolus dosing of valproate during ECT sessions improved mania symptoms in a patient.
- Valproate was administered at each ECT session, leading to progressively better outcomes.
- This approach offers a potential treatment strategy for ECT-induced mania.

## Abstract

Electroconvulsive therapy (ECT) is an effective treatment for various mental illnesses. While it is an excellent modality in treating depression and severe mania, it can also induce mania in certain specific settings. There is so far scarce literature regarding the management of ECT-induced mania with antipsychotics and mood stabilizers, specifically lithium, utilized in different studies. Moreover, there is limited evidence for using valproate for the symptoms. We present a case vignette about managing mania symptoms after ECT by administering a bolus dose of valproate at each session, resulting in progressively improved outcomes.

## Linked entities

- **Chemicals:** valproate (PubChem CID 3549980)

## Full-text entities

- **Diseases:** depression (MESH:D003866), Mania (MESH:D001714), mental illnesses (MESH:D001523)
- **Chemicals:** stabilizers (-), Valproate (MESH:D014635), lithium (MESH:D008094)

## Full text

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## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11821558/full.md

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Source: https://tomesphere.com/paper/PMC11821558