# Synthesis and Characterization of a Pla Scaffold with Pseudoboehmite and Graphene Oxide Nanofillers Added

**Authors:** Rafael Vieira Maidana, Antônio Hortêncio Munhoz, Filipe Figueiredo Ramos, Alex Lopes de Oliveira, José César de Souza Almeida Neto, Victor Inácio de Oliveira, Bruno Luis Soares de Lima, Fábio Jesus Moreira de Almeida

PMC · DOI: 10.3390/nano15030167 · Nanomaterials · 2025-01-22

## TL;DR

This paper explores a new biodegradable scaffold made of PLA with added pseudoboehmite and graphene oxide to improve its durability and performance for skin grafts.

## Contribution

The novel contribution is the development of a PLA scaffold enhanced with pseudoboehmite and graphene oxide nanofillers to improve mechanical properties.

## Key findings

- SEM, EDS, and XRD analyses confirmed the presence and distribution of pseudoboehmite and graphene oxide in the scaffold.
- The modified scaffold showed increased stress resistance, reduced deformation, and improved toughness compared to pure PLA.
- Adding the nanofillers enhanced the mechanical and thermal properties of the biodegradable scaffold.

## Abstract

In cases of severe injuries or burns, skin grafts (scaffolds) are often required as skin substitutes. In order not to harm the patient or the donor, biodegradable and biocompatible materials are used, which validates the search for heterografts such as poly (L-lactic acid)—PLA. However, natural polymers applied to the skin suffer great degradation in environments with large amounts of carbon and water or via binders with considerable resistivity, which implies little durability due to their low ductility. For the proposal, this work investigates PLA-based scaffolds modified with a mixture of pseudoboehmite (PB) and graphene oxide (GO), produced via the sol–gel route. The nanomaterials are incorporated into the polymer at different loadings, seeking to improve mechanical and thermal properties. Analyses via SEM, EDS, and XRD confirm the presence and distribution of these fillers. Tensile and flexural tests indicate that adding the filler can increase stress resistance, prevent deformations before failure, and increase toughness when compared to pure PLA.

## Linked entities

- **Chemicals:** pseudoboehmite (PubChem CID 73982)

## Full-text entities

- **Diseases:** burns (MESH:D002056)
- **Chemicals:** PLA (MESH:C033616), GO (MESH:C000628730), carbon (MESH:D002244), PB (-), water (MESH:D014867), polymer (MESH:D011108)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC11820932/full.md

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Source: https://tomesphere.com/paper/PMC11820932