# Synthesis of (1,10-Phenanthroline-κ2N,N′)(β2-Methyl- and β2-PhenylAlaninate-κ2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines

## TL;DR

This paper reports the synthesis and testing of two new copper-based compounds for their potential to fight breast and lung cancer.

## Contribution

The study introduces two new Casiopeínas® complexes with β2-aminoacidate ligands and evaluates their antiproliferative activity.

## Key findings

- The compounds were characterized using advanced analytical techniques.
- The complexes showed antiproliferative activity against MCF-7 and A549 cancer cell lines.
- Structural details were confirmed via single crystal X-ray diffraction.

## Abstract

In recent years, metallodrugs have been playing an important role, showing to be more efficient in the treatment of several diseases, such as cancer. Indeed, it is important to synthesize novel molecules to be used as more effective agents against cancer. In the present paper, the synthesis of two new molecules belonging to Casiopeínas® is reported. These compounds present a β2-aminoacidate derivative as the secondary ligand. The novel metal complexes were characterized by high-resolution mass spectrometry, FT-IR, UV-Vis, EPR, effective magnetic moment and cyclic voltammetry measurements, and single crystal X-ray diffraction analysis. Furthermore, these compounds were evaluated in vitro against the cancer lines MCF-7 (breast cancer) and A549 (lung cancer).