# Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety

## TL;DR

Researchers synthesized new diterpenoid compounds with anti-inflammatory properties, some of which showed strong effects in cell tests.

## Contribution

The paper introduces novel diterpenoid hybrids with a triazole moiety and demonstrates their potent anti-inflammatory activity.

## Key findings

- Several compounds exhibited strong anti-inflammatory activity on BV2 cell lines.
- Compounds 10, 15, 16, and 17 had IC50 values below 11 µM, indicating high potency.
- The compounds were characterized using NMR and ESI-HRMS for structural confirmation.

## Abstract

To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of 1H NMR, 13C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC50 = 42.36 ± 2.47 µM) as a positive control. Most showed good anti-inflammatory activities, especially compounds 10 (IC50 = 8.40 ± 0.98 µM), 15 (IC50 = 10.74 ± 2.67 µM), 16 (IC50 = 10.96 ± 1.85 µM), and 17 (IC50 = 9.76 ± 1.27 µM), which exhibited potent anti-inflammatory effects on BV2 cell lines.