The Role of the Functionalization of Biomedical Fabrics on Their Ability to Adsorb and Release Drugs

TL;DR

This paper shows how modifying cotton gauze with chemical groups improves its ability to absorb and release drugs like ibuprofen and amoxicillin.

Contribution

The study introduces a new method of functionalizing biomedical fabrics to enhance drug adsorption and controlled release.

Findings

Functionalized gauzes C2–C5 adsorbed up to 0.8 mmol g−1 of ibuprofen and 0.4 mmol g−1 of amoxicillin.

Drug release was significantly higher in physiological saline than in deionized water.

Gauzes with amino groups (C3–C5) adsorbed more drugs, while C2 released drugs more quickly.

Abstract

Biomedical cotton gauzes (C0), after a first functionalization with glycidyl methacrylate (GMA) by a Fenton’s reaction (material C1), can be further modified in order to make them suitable for the adsorption and next release of drugs. Indeed, either after opening the epoxide ring through the addition of water (material C2) or after the introduction of amino groups through reaction with diamines (1,2-diaminoethane (material C3), 1,6-diaminohexane (material C4) and 1,12-diaminododecane (material C5)), the new gauzes can be uploaded with drugs. Both ibuprofen (IB), a non-steroidal anti-inflammatory, and amoxicillin (AM), a wide-spectrum β-lactam antibiotic, are efficiently adsorbed from their aqueous solutions at 20 °C onto C2–C5 (up to ≈0.8 mmol g−1 for IB and up to 0.4 mmol g−1 for AM) but not onto C0 and C1. The release of both IB and AM is affected by the ionic strength of the medium in which the release takes place. Indeed, kinetic experiments conducted with a physiological solution (NaCl (aq, 0.9% w/v) showed good release efficiencies while only modest or negligible release was observed if deionised water was the release medium. Moreover, the kind of functionalization plays an important role during both the adsorption and the release. The gauzes C3–C5 can be uploaded with a higher amount of drug relative to C2. Conversely, the drug is released quickly and in a higher amount from C2 relative to the gauzes containing the amino groups.

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