# A Joint Analysis of RNA-DNA and DNA-DNA Interactomes Reveals Their Strong Association

## TL;DR

This study shows that RNA-DNA interactions and chromatin structure are closely linked in human and mouse cells, with relationships that are both tissue-specific and conserved.

## Contribution

The paper introduces a comprehensive joint analysis linking RNA-DNA interactions with chromatin structure across multiple cell lines.

## Key findings

- RNA-DNA and DNA-DNA interactions are strongly associated in chromatin processes.
- The relationship between these interactions is tissue-specific and conserved across species.
- The analysis was conducted across different human and mouse cell lines.

## Abstract

At the moment, many non-coding RNAs that perform a variety of functions in the regulation of chromatin processes are known. An increasing number of protocols allow researchers to study RNA-DNA interactions and shed light on new aspects of the RNA–chromatin interactome. The Hi-C protocol, which enables the study of chromatin’s three-dimensional organization, has already led to numerous discoveries in the field of genome 3D organization. We conducted a comprehensive joint analysis of the RNA-DNA interactome and chromatin structure across different human and mouse cell lines. We show that these two phenomena are closely related in many respects, with the nature of this relationship being both tissue specific and conserved across humans and mice.