# Case report of early signs of aortic stenosis decompensation detected via ambient sensor-derived digital biomarkers

## TL;DR

This case report shows how home sensors detected early signs of aortic stenosis worsening in an elderly woman before hospitalization.

## Contribution

Demonstrates the use of ambient sensors to detect pre-clinical signs of aortic stenosis decompensation in a real-world case.

## Key findings

- Increased night-time heart rate and respiration were observed months before hospitalization.
- Reduced physical activity and increased toilet visits were early indicators of decompensation.
- Ambient sensors identified subtle changes that preceded clinical symptoms.

## Abstract

Aortic stenosis is a progressive condition with a grim prognosis, underscoring the importance of timely intervention to prevent decompensation. Home monitoring systems, particularly those utilizing ambient sensors, offer promise in detecting early signs of deterioration.

We present the case of an 89-year-old woman who was asymptomatic but monitored using such a system prior to experiencing acute decompensation. Key clinical indicators, including increased night-time heart rate, respiration rate, toss and turns in bed, and nocturia, were observed several months before hospitalization. Additionally, reduced physical activity and increased toilet visits were noted.

These findings highlight the potential of ambient sensor systems in identifying pre-clinical stages of cardiac decompensation, especially in severe aortic stenosis cases. Integrating ambient sensor systems into routine clinical practice holds promise for enhancing proactive management strategies and reducing adverse outcomes associated with cardiovascular disease progression.