# Diagnostic Challenge of Localized Tenosynovial Giant Cell Tumor in Children

**Authors:** Jiro Ichikawa, Satoshi Ochiai, Tomonori Kawasaki, Kojiro Onohara, Masanori Wako, Hirotaka Haro, Tetsuo Hagino

PMC · DOI: 10.3390/diagnostics15030281 · Diagnostics · 2025-01-24

## TL;DR

A 9-year-old boy's knee pain was initially misdiagnosed, but he was later found to have a rare tumor, highlighting the challenges in diagnosing pediatric knee issues.

## Contribution

The paper presents a rare pediatric case of localized TSGCT misdiagnosed as arthritis, emphasizing the need for MRI and histopathological confirmation.

## Key findings

- The patient's symptoms were initially misdiagnosed as arthritis and a fibroma, delaying proper treatment.
- MRI revealed a tumor, and surgery confirmed the diagnosis of localized TSGCT.
- The patient remained asymptomatic six months post-surgery, showing successful treatment.

## Abstract

This report describes a rare case of a pediatric tenosynovial giant cell tumor (TSGCT) with a delayed diagnosis. A 9-year-old boy presented with a 3-month history of knee pain and swelling, initially attributed to a femoral non-ossifying fibroma and arthritis based on computed tomography findings and slightly elevated C-reactive protein levels. The symptoms persisted despite medical treatment. Magnetic resonance imaging (MRI) revealed a tumor in the posterior compartment. He underwent surgery, and the pathology confirmed the diagnosis of localized TSGCT. Six months postoperatively, the patient remained asymptomatic. Pediatric knee pain is a complex symptom associated with inflammatory conditions and benign and malignant tumors. Benign tumors, as in this case, can be misdiagnosed as arthritis, delaying diagnosis and treatment. MRI is recommended in cases involving symptom persistence. However, histopathological, immunohistochemical, and morphological examinations are crucial for definitive diagnosis, particularly when the imaging findings are inconclusive.

## Linked entities

- **Diseases:** arthritis (MONDO:0005578), tenosynovial giant cell tumor (MONDO:0002522)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** inflammatory (MESH:D007249), arthritis (MESH:D001168), TSGCT (MESH:D000070779), Benign tumors (MESH:D009369), swelling (MESH:D004487), femoral non-ossifying fibroma (MESH:D018214), knee pain (MESH:D046788)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11816834/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11816834/full.md

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Source: https://tomesphere.com/paper/PMC11816834