# Effects of Turmeric and Rosemary Extract on Oxidative Stress Markers in Goats

## TL;DR

This study shows that a turmeric and rosemary extract supplement can boost antioxidant defenses in goats without harming their liver function.

## Contribution

The study introduces a natural supplement combination that enhances antioxidant defenses in goats.

## Key findings

- Supplementation reduced lipoperoxidation and increased total antioxidant capacity.
- Liver enzyme activities remained stable, indicating no adverse effects.
- Protein oxidation increased, possibly due to lipid peroxidation metabolites.

## Abstract

Animal welfare is a primary concern within the development of livestock farming and animal health is one of the major issues it refers to. It is possible for organisms to be protected against many diseases due to the proper functioning of the immune system. Oxidative stress can cause damage to DNA, proteins, and lipids in cells. Consequently, it can lead to cell and tissue damage. Natural and easy-to-produce supplements are increasingly used in farming. We hypothesized that polyphenols influence oxidative stress. Therefore, the aim of our study was to analyze the effect of supplementation with a dried turmeric and rosemary extract mixture on the oxidative stress markers in the blood serum of young castrated bucks of the Polish White Improved (PWI) breed. We suggest that supplementation effectively enhanced antioxidant defenses without adversely affecting liver enzyme activities: a favorable biochemical response. However, further studies are needed to determine the effect of different doses of the dry turmeric–rosemary mixture.

Background: Due to their versatility, goats are becoming popular as livestock on commercial farms. To obtain a high productivity, the maintenance of homeostasis in these organisms is needed. Some supplements that could help improve their health state have been tested recently. The study examines the effects of a turmeric–rosemary extract mixture on the antioxidant status of the blood of young castrated bucks. Results: Supplementation lowered lipoperoxidation and increased TAC, probably due to the improved neutralization of reactive oxygen species (ROS) by enhanced antioxidant pathways. Despite lowering lipid peroxidation, these products can increase protein oxidation. Thus, while enhancing lipid defense mechanisms may reduce lipid peroxidation, it may also increase the level of OMP, probably due to the accumulation of lipid peroxidation metabolites. The activities of SOD, GPx, and GR remained unchanged, whereas CAT activity decreased. CP, ALT, and AST remained stable, suggesting no adverse effects on key markers of liver function. Conclusions: The high antioxidant potential observed after supplementation indicates that the turmeric–rosemary extract mixture elicited a favorable biochemical response; the supplemented compounds effectively enhanced antioxidant defenses (by improving the neutralization of ROS) without negatively affecting liver enzyme activities. Turmeric–rosemary dry extract supplementation can help with homeostasis maintenance in goat organisms and, consequently, improve their productivity.