# Encapsulating Peritoneal Sclerosis Improvement Following Conservative Treatment in a Child Undergoing Peritoneal Dialysis

**Authors:** John Dotis, Antonia Kondou, Vasiliki Karava, Nikoleta Printza

PMC · DOI: 10.7759/cureus.77359 · Cureus · 2025-01-13

## TL;DR

A child with peritoneal dialysis developed encapsulating peritoneal sclerosis but improved with conservative treatment using prednisone and tamoxifen.

## Contribution

Demonstrates successful non-surgical treatment of EPS in a child using corticosteroids and tamoxifen.

## Key findings

- EPS was diagnosed early using abdominal CT in a five-year-old undergoing peritoneal dialysis.
- Conservative treatment with prednisone and tamoxifen led to improvement without the need for surgery.

## Abstract

Encapsulating peritoneal sclerosis (EPS) constitutes a rare but one of the most serious complications of long-term peritoneal dialysis (PD) in children. The role of abdominal computed tomography (CT) imaging in the early recognition and management of EPS is of great importance and should be performed promptly to establish diagnosis. This fact can provide an opportunity for conservative treatment with corticosteroids and tamoxifen, as it appears that early treatment can have beneficial effects. Based on the above, we present a five-year-old girl undergoing PD who developed EPS established by abdominal CT, who was withdrawn from the PD method but was successfully treated with a combination of prednisone and tamoxifen without the need for a surgical approach.

## Linked entities

- **Chemicals:** prednisone (PubChem CID 5865), tamoxifen (PubChem CID 2733526)
- **Diseases:** encapsulating peritoneal sclerosis (MONDO:1010131)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** EPS (MESH:D056627)
- **Chemicals:** prednisone (MESH:D011241), tamoxifen (MESH:D013629)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11815527/full.md

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Source: https://tomesphere.com/paper/PMC11815527