# Epidemiological characterization of congenital heart disease at different altitudes in Ecuador: a four-year retrospective study in a pediatric referral hospital

## TL;DR

This study examines the patterns of congenital heart disease in Ecuadorian children, finding that most cases are acyanotic and more common at high altitudes.

## Contribution

The study provides the first detailed epidemiological analysis of CHD in Ecuador, focusing on altitude-related patterns and gender differences.

## Key findings

- 71.4% of CHD cases were acyanotic, with patent ductus arteriosus being the most common type.
- Most patients (65.2%) lived at high altitudes, but no clear altitude-specific CHD patterns were identified.
- Mortality was higher in acyanotic CHD cases, and disability burden was significant among these patients.

## Abstract

Congenital heart disease (CHD) is one of the main causes of hospital admissions and infant mortality, especially in developing regions.

This study aims to describe the epidemiological and clinical features of CHD in pediatric patients, from one of the largest tertiary-level national referral pediatric hospitals in Ecuador.

An epidemiological, retrospective cohort study was conducted among patients with CHD who were hospitalized at “Hospital Baca Ortiz” between January 2019 to December 2022 in Quito, Ecuador.

A total of 1,000 pediatric patient medical records were reviewed from 2019 to 2022. Among these patients, 56.0% were female, and 65.2% resided at high altitudes (2,500–3,500 m). Most cases (71.4%) were acyanotic CHD, with patent ductus arteriosus being the most prevalent (48.7%). Among cyanotic CHD, Tetralogy of Fallot was predominant (28.1%). Mortality was observed in 5.3% of patients, with a higher rate among acyanotic CHD (p < 0.001).

Most cases of CHD were of the acyanotic type, predominantly affecting female patients. Although most cases occurred in children living above 2,500 meters, no clear influence of altitude on specific types of CHD was found. While mortality related to CHD was low, the burden of disability from these conditions was significant among patients with acyanotic CHD.