# Coexistence of Lichen Sclerosus and Morphea in a Single Vulvar Lesion

**Authors:** Kazuyoshi Iijima, Yoshihito Mima

PMC · DOI: 10.7759/cureus.77303 · 2025-01-11

## TL;DR

This paper reports a rare case where two skin conditions, lichen sclerosus and morphea, coexist in a single genital lesion, highlighting diagnostic challenges.

## Contribution

The novelty lies in documenting the coexistence of lichen sclerosus and morphea within a single vulvar lesion, suggesting they may be part of a shared disease spectrum.

## Key findings

- A 60-year-old female presented with a vulvar lesion showing clinical features of lichen sclerosus.
- Histological analysis revealed characteristics of both lichen sclerosus and morphea in the same lesion.
- The case suggests that lichen sclerosus and morphea may represent overlapping manifestations of a single disease spectrum.

## Abstract

Lichen sclerosus (LS) and morphea are chronic inflammatory disorders with overlapping clinical and histopathological features, often complicating diagnosis. While the co-occurrence of LS and morphea as distinct lesions in the same patient is well documented, their overlap within a single lesion is rare, especially in genital regions. Herein, we present a case of a 60-year-old female with coexisting LS and morphea in the genital region, exhibiting features of LS while demonstrating histological characteristics of both. This case underscores the diagnostic challenges and provides further support for the possibility that LS and morphea may represent varying manifestations within a shared disease spectrum.

## Linked entities

- **Diseases:** Lichen Sclerosus (MONDO:0007899), morphea (MONDO:0019562)

## Full-text entities

- **Diseases:** Vulvar Lesion (MESH:D014845), inflammatory disorders (MESH:D007249), Morphea (MESH:D012594), LS (MESH:D018459)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11813640/full.md

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Source: https://tomesphere.com/paper/PMC11813640