# 2020 Grand challenge revisited: removing silos, advancing research to improve overall health

**Authors:** Martha J. Somerman, Wendy E. Mouradian, Sukirth M. Ganesan

PMC · DOI: 10.3389/fdmed.2024.1430828 · 2024-07-11

## TL;DR

This paper highlights the importance of integrating dental, oral, and craniofacial research with broader biomedical fields to improve overall health through collaboration.

## Contribution

It emphasizes the ongoing need to foster interprofessional research and collaboration in this area for continued innovation.

## Key findings

- Integration of dental and biomedical research is crucial for advancing overall health.
- Interprofessional collaborations are key to achieving progress in this field.
- Continued momentum is needed to inform and engage stakeholders in applying new knowledge.

## Abstract

This perspective provides strong evidence that the aims set forth when Frontiers in Dental Medicine (FDMED) was launched in 2020, to advance the integration of dental, oral, and craniofacial research with mainstream biomedical practice, underscored the value of interprofessional research collaborations, encouraging studies, publications, and commentaries in this area ripe for continued innovation. The momentum gained toward these aims must continue to inform the public, healthcare providers, researchers, educators, and policymakers so that they can apply the knowledge gained to improve the overall health needs of all our communities.

## Full-text entities

- **Genes:** TNAP [NCBI Gene 445341], ALPL (alkaline phosphatase, biomineralization associated) [NCBI Gene 249] {aka AP-TNAP, APTNAP, HOPS, HPPA, HPPC, HPPI}, TNFSF11 (TNF superfamily member 11) [NCBI Gene 8600] {aka CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B}
- **Diseases:** craniofacial conditions (MESH:D005157), periodontitis (MESH:D010518), xerostomia (MESH:D014987), HPP (MESH:D007014), cardiovascular diseases (MESH:D002318), asthma (MESH:D001249), overweight (MESH:D050177), T2D (MESH:D003924), obese (MESH:D009765), DOC (MESH:D019465), oral health conditions (MESH:D000071069), rickets (MESH:D012279), chronic diseases (MESH:D002908), oral diseases (MESH:D009059), Dental Medicine (MESH:D009057), rheumatic diseases (MESH:D012216), osteoporosis (MESH:D010024), neurogenerative conditions (MESH:D001750), pneumonia (MESH:D011014), depression (MESH:D003866), bone loss (MESH:D001847), cancer (MESH:D009369), mineralized (MESH:C537337), infection (MESH:D007239), NCDs (MESH:D000073296), metabolic (MESH:D008659), MetS (MESH:D024821), periodontal disease (MESH:D010510), inflammatory (MESH:D007249), CAD (MESH:D003324), systemic diseases (MESH:D034721), colon cancer (MESH:D015179), osteomalacia (MESH:D010018), osteonecrosis of the jaw (MESH:D059266), COVID-19 (MESH:D000086382), disease (MESH:D004194), Alzheimer's disease (MESH:D000544), Oral Health (OMIM:603663), diabetes (MESH:D003920), inflammatory bowel disease (MESH:D015212)
- **Chemicals:** teriparatide (MESH:D019379), DOC (-), BP (MESH:D004164), phosphate (MESH:D010710), pyrophosphate (MESH:C107241), denosumab (MESH:D000069448)
- **Species:** Streptococcus (genus) [taxon 1301], Homo sapiens (human, species) [taxon 9606], Fusobacterium nucleatum (species) [taxon 851], Porphyromonas gingivalis (species) [taxon 837], Helicobacter pylori (species) [taxon 210], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Mus musculus (house mouse, species) [taxon 10090]

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Source: https://tomesphere.com/paper/PMC11811776