# Association Between Anti‐TIF1‐γ Antibody and Triple‐Negative Breast Carcinoma in Dermatomyositis Patients: A Case Report

**Authors:** Fan Zhang, Hailing Guo, Jia Ma

PMC · DOI: 10.1002/ccr3.70157 · 2025-02-10

## TL;DR

This case report explores a possible link between anti-TIF1-γ antibodies and triple-negative breast cancer in a patient with dermatomyositis.

## Contribution

The paper presents a case suggesting a potential association between anti-TIF1-γ antibodies and triple-negative breast carcinoma in dermatomyositis.

## Key findings

- Anti-TIF1-γ antibody is more common in DM patients with cancer.
- A case is presented where anti-TIF1-γ antibody was associated with triple-negative breast carcinoma.
- This suggests a possible clinical link between the antibody and this cancer subtype.

## Abstract

Dermatomyositis (DM) is always associated with various types of malignancies in previously published reports. Anti‐transcription intermediary factor 1‐γ (anti‐TIF1‐γ) antibody is more prevalent in DM patients with malignancy than in those without malignancy. In this paper, we want to show a possible relation between anti‐TIF1‐γ and triple‐negative breast carcinoma.

## Linked entities

- **Proteins:** TRIM33 (tripartite motif containing 33)
- **Diseases:** dermatomyositis (MONDO:0016367), triple-negative breast carcinoma (MONDO:0005494)

## Full-text entities

- **Genes:** TRIM33 (tripartite motif containing 33) [NCBI Gene 51592] {aka DDH4, ECTO, PTC7, RFG7, TF1G, TIF1G}
- **Diseases:** DM (MESH:D003882), malignancies (MESH:D009369), Breast Carcinoma (MESH:D001943)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11811392/full.md

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Source: https://tomesphere.com/paper/PMC11811392