# The controls that got out of control: How failed control experiments paved the way to transformative discoveries

**Authors:** André Schneider

PMC · DOI: 10.1038/s44319-025-00369-w · EMBO Reports · 2025-01-20

## TL;DR

This paper discusses how failed control experiments can lead to unexpected and transformative scientific discoveries.

## Contribution

It highlights the novel perspective that experimental failures can be a source of important new insights.

## Key findings

- Failed controls can signal unexpected phenomena.
- Such failures can lead to transformative discoveries.
- Scientists should consider failed controls as potential opportunities.

## Abstract

When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.

## Full-text entities

- **Genes:** Epo (erythropoietin) [NCBI Gene 13856], par-1 (Serine/threonine-protein kinase par-1) [NCBI Gene 179912]
- **Diseases:** oocyte abnormalities (OMIM:615774), birth defects (MESH:D000014), chromosomal abnormalities (MESH:D002869), infertility (MESH:D007246), miscarriage (MESH:D000022), hepatoma (MESH:D006528)
- **Chemicals:** BPA (MESH:C006780), GTP (MESH:D006160), drinking water (MESH:D060766), oxygen (MESH:D010100), ATP (MESH:D000255), polysulfone (MESH:C017662), polystyrene (MESH:D011137), Magnesium (MESH:D008274), proline (MESH:D011392)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bacillus subtilis (species) [taxon 1423], C. elegans [taxon 328850], Mus musculus (house mouse, species) [taxon 10090], Tetrahymena (genus) [taxon 5890], Escherichia coli (E. coli, species) [taxon 562]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11811022/full.md

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Source: https://tomesphere.com/paper/PMC11811022