# A Rare Case of Benign Phyllodes Tumor of the Breast Responding to Anastrozole

**Authors:** Patrícia R Rodrigues, Diana Mata, José Brito-da-Silva, Carolina P Duque, Ana Ferreira

PMC · DOI: 10.7759/cureus.77277 · Cureus · 2025-01-11

## TL;DR

This paper reports a rare case where a benign breast tumor responded to anastrozole, a drug not typically used for such tumors.

## Contribution

The paper presents the first documented case of a phyllodes tumor responding to anastrozole treatment.

## Key findings

- A large phyllodes tumor showed a clinical response to anastrozole.
- This case suggests a potential role for endocrine therapy in treating phyllodes tumors.

## Abstract

A phyllodes tumor is a rare fibroepithelial breast tumor that can be benign, borderline, or malignant. Its diagnosis is challenging because it shares characteristics with other lesions. The treatment is primarily surgical, with no established role for chemotherapy and limited evidence supporting radiotherapy. There is no evidence of phyllodes tumors expressing endocrine receptors, nor is there an established role for endocrine therapy in treating these tumors. We present a case of a large phyllodes tumor that showed a clinical response to treatment with anastrozole.

## Linked entities

- **Chemicals:** anastrozole (PubChem CID 2187)
- **Diseases:** phyllodes tumor (MONDO:0005078)

## Full-text entities

- **Diseases:** phyllodes tumor (MESH:D003557), Benign Phyllodes Tumor of the Breast (MESH:D001943), tumors (MESH:D009369)
- **Chemicals:** Anastrozole (MESH:D000077384)

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11809272/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11809272/full.md

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Source: https://tomesphere.com/paper/PMC11809272