# Brain anatomy differences in Chinese children who stutter: a preliminary study

## TL;DR

This study explores brain structure differences in Chinese children who stutter, finding reduced gray matter in specific regions linked to stuttering severity.

## Contribution

The study identifies specific brain regions associated with stuttering in Chinese children, linking structural changes to stuttering severity.

## Key findings

- Gray matter volume is significantly decreased in the right temporal gyrus and bilateral cerebellum in children who stutter.
- Cortical folds are reduced in the right insula and right superior temporal gyrus in stuttering children.
- Gray matter volume in the right cerebellum and right temporal gyrus correlates with stuttering severity scores.

## Abstract

It is unknown the neural mechanisms of developmental stuttering (DS). The aim of this study was to investigate the changes in the structural morphology of the brain in Chinese children who stutter.

A case–control study was conducted to collect magnetic resonance imaging data from stuttering and non-stuttering children, thereby analyzing whole-brain gray matter volume and cortical morphological changes in stuttering children.

A total of 108 subjects were recruited (stuttering group: control group = 1:1). Comparing to healthy controls, the gray matter volume was significantly decreased in right temporal gyrus and bilateral cerebellum. Additionally, there was a significant reduction in cortical folds in the right insula and right superior temporal gyrus. Moreover, the gray matter volume of the right cerebellum and right temporal gyrus is related to the severity score of stuttering.

The present study proposes that the neural mechanisms underlying DS are intricately linked to the cortico-basal ganglia-thalamo-cortical loop and the dorsal language pathway. This finding is expected to provide reference value for the clinical treatment of DS.