# Global Sensitivity Analysis of a Novel Signaling Network for Heart Growth With Local IGF1 Production

## TL;DR

The study identifies key factors influencing heart growth through a sensitivity analysis of a signaling network, emphasizing the role of locally produced IGF1.

## Contribution

The novel incorporation of local IGF1 production in response to mechanical stretch significantly improves heart growth modeling.

## Key findings

- Local IGF1 production significantly increases the influence of mechanical stretch on heart growth.
- Norepinephrine (NE), angiotensin II (AngII), and globally produced IGF1 (g-IGF1) are key influential factors.
- Global sensitivity analysis reveals the importance of integrating local IGF1 in heart growth signaling networks.

## Abstract

Signaling networks can be used to describe the dynamic interplay of hormonal and mechanical factors that regulate heart growth. However, a qualitative analysis of signaling networks is often difficult due to their complexity and nonlinear behavior. In this work, a global sensitivity analysis of signaling networks is conducted to determine the most influential factors for heart growth over a range of model inputs. Furthermore, the local production of the hormone insulin‐like growth factor 1 (IGF1) in response to high mechanical stretches as recently described by Zaman et al.(Immunity, 54, 2057) and Wong et al.(Immunity, 54, 2072) is incorporated. The computational results show that this increases the influence of mechanical stretch on heart growth significantly. Further key influential factors are the hormones norepinephrine (NE), angiotensin II (AngII), and globally produced IGF1 (g‐IGF1). Our sensitivity analysis indicates that the novel consideration of local IGF1 (l‐IGF1) production has to be considered in signaling networks for heart growth.

Signaling networks regulate heart growth through hormonal and mechanical factors, but their complexity makes qualitative analysis challenging. This study's global sensitivity analysis highlights key factors, including the significant impact of local insulin‐like growth factor 1 (IGF1) production in response to mechanical stretches, norepinephrine (NE), angiotensin II (AngII), and globally produced IGF1 (g‐IGF1). Incorporating local IGF1 production is crucial for accurate heart growth modeling.