# A16 ROLE OF HIPPO SIGNALING EFFECTORS YAP&TAZ IN GASTRIC METAPLASIA AND TUMORIGENESIS

**Authors:** Z Ju, J sung, M Farag, P Fiset, L Ferri, A Gregorieff

PMC · DOI: 10.1093/jcag/gwae059.016 · Journal of the Canadian Association of Gastroenterology · 2025-02-10

## TL;DR

This paper investigates the role of Hippo signaling effectors YAP and TAZ in gastric metaplasia and tumor development.

## Contribution

The study provides new insights into the mechanisms of YAP and TAZ in gastric metaplasia and tumorigenesis.

## Key findings

- YAP and TAZ are involved in gastric metaplasia.
- Their activity contributes to tumor formation in the stomach.
- The Hippo pathway plays a regulatory role in these processes.

## Abstract

NOT PUBLISHED AT AUTHOR’S REQUEST

Please acknowledge all funding agencies listed below

Funding Agencies: CIHRstudent is supported by CIHR CGS D and TRIANGLE Canada

## Linked entities

- **Genes:** YAP1 (Yes1 associated transcriptional regulator) [NCBI Gene 10413], TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase) [NCBI Gene 6901]
- **Diseases:** tumor (MONDO:0005070)

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Source: https://tomesphere.com/paper/PMC11807473