# The Association Between Pre-morbid Frailty and Discontinuation of Treatment Within 24 Hours in Critically Ill Older Adults Triaged to a Tertiary Care Emergency Department: A Retrospective Cohort Study

## TL;DR

This study found that higher pre-morbid frailty scores in older adults are linked to a greater chance of discontinuing treatment within 24 hours in the emergency department.

## Contribution

The study identifies pre-morbid Clinical Frailty Scale scores as a potential indicator for early goals-of-care conversations in critically ill older adults.

## Key findings

- 58 out of 407 patients (14.2%) withdrew from intensive care within 24 hours.
- Higher CFS scores (7-9) were significantly associated with treatment withdrawal (adjusted odds ratio = 5.48).
- CFS scores 5 and 6 showed increased but non-significant odds of treatment withdrawal.

## Abstract

Background

Some critically ill older adults would rather receive palliative than intensive care if their functional capacity and quality of life are compromised. Therefore, careful goals-of-care conversation is vital in frail older adults who are critically ill if there is no advance care planning before arrival at the emergency department. We considered that pre-morbid Clinical Frailty Scale (CFS) scores could be a potent factor in prioritizing such conversations if higher numbers were associated with increased withdrawal of treatment in these patients. This study aimed to investigate the association between pre-morbid frailty and discontinuation of treatment within 24 hours in older adults in Kobe, Japan.

Methodology

This retrospective, observational study was conducted among patients aged 65 and over who were triaged as needing tertiary care to our emergency department with subsequent admission for further treatment. The primary outcome was withdrawal of treatment within 24 hours. We examined the association between CFS and withdrawal of treatment using a multivariable logistic regression model with CFS 1-4 as a reference.

Results

During the study period, 1,093 patients were triaged to our emergency department as needing tertiary care. After exclusion, 407 patients (median age = 80 years (interquartile range = 73-87)), were included in the study. Of these, 58 (14.2%) patients withdrew from intensive care within 24 hours. The adjusted odds ratios were 1.99 for CFS 5 (95% confidence interval (CI) = 0.74-5.32, p = 0.17), 2.48 for CFS 6 (95% CI = 0.93-6.57, p = 0.068), and 5.48 for CFS 7-9 (95% CI = 2.68-12.6, p < 0.01).

Conclusions

Higher CFS scores in critically ill older adults were associated with a higher likelihood of withdrawal within 24 hours. The goals-of-care conversation could be held proactively when CFS scores are high to reduce unwanted medical intervention.