# A pilot study comparing the rehabilitation functional outcomes of post-COVID-19 stroke and non-COVID stroke patients: An occupational therapy perspective

## TL;DR

This study compares the rehabilitation outcomes of stroke patients with and without a history of COVID-19, finding that non-COVID stroke patients showed greater functional improvement.

## Contribution

The study introduces a novel occupational therapy perspective on post-COVID-19 stroke rehabilitation outcomes.

## Key findings

- Non-COVID stroke patients showed higher mean functional improvements than post-COVID-19 stroke patients.
- Age and impaired side influenced outcomes in post-COVID-19 stroke patients.
- Effective rehabilitation led to functional gains in both groups.

## Abstract

Background and purpose: Recent studies have highlighted the clinical characteristics and incidence of post-COVID-19 stroke conditions. Comparing the function and overall prognosis of stroke patients and post-COVID-19 stroke patients is an intriguing idea. Therefore, the aim of this study was to examine and compare the functional outcomes between the two groups from an occupational therapy perspective.

Methods: Forty patients admitted to a rehabilitation facility were included, 20 of whom were diagnosed with post-COVID-19 stroke and 20 with non-COVID-19 stroke (ischemic and hemorrhagic). The study was a mixed design consisting of both prospective and retrospective data collection. Existing data from electronic medical records were used for the retrospective dataset. The retrospective dataset only consisted of data from post-COVID-19 stroke patients. The prospective dataset consisted of data from non-COVID-19 stroke patients. Data were collected at the time of admission and at discharge. Outcome measures included the functional independence measure (FIM), the Action Research Arm Test (ARAT), the post-COVID-19 functional status (PCFS) scale, the Borg rating of perceived exertion, and the mini-mental state examination (MMSE).

Results: Both the post-COVID-19 stroke and non-COVID stroke groups showed significant differences before and after rehabilitation (NIHSS (National Institutes of Health Stroke Scale): p = 0.014, 0.000, FIM: p = 0.000, 0.000, MMSE: p = 0.015, 0.000, ARAT: p = 0.000, 0.000, respectively). However, the mean difference in the non-COVID-19 stroke group was higher than that in the post-COVID-19 stroke group, particularly in MMSE, FIM, and NIHSS scores (NIHSS: 2.8 ± 0.4, 0.9 ± 0.04, FIM: 34.8 ± 5.03, 32.95 ± 0.81, MMSE: 5.05 ± 3.5, 0.7 ± 1.17, ARAT: 1 ± 0.062, 1.2 ± 0.47, respectively). It was also found that in the post-COVID-19 stroke group, age had a positive influence on NIHSS (p = 0.022) and FIM (p = 0.047), and impaired side affected the NIHSS scores (p = 0.007). In the non-COVID-19 stroke group, significant correlations were found between the NIHSS and FIM scores (r = -0.445, p = 0.050) and the NIHSS and ARAT scores (r = -0.529, p = 0.017).

Conclusion: Higher mean differences in the non-COVID-19 stroke group than in the post-COVID-19 group could be due to additional COVID-19 complications in the stroke condition itself. Overall functional gain was observed in both groups due to the effective rehabilitation. Therefore, rehabilitation is critical for functional optimization in such vulnerable populations. There is an urgent need to consider post-pandemic rehabilitation aspects.