# RETRACTION: LncRNA CCAT2 Promotes the Proliferation and Metastasis of Colorectal Cancer Through Activation of the ERK and Wnt Signaling Pathways by Regulating GNB2 Expression

PMC · DOI: 10.1002/cam4.70616 · Cancer Medicine · 2025-02-07

## TL;DR

This retracted study claimed that the lncRNA CCAT2 promotes colorectal cancer growth and spread by activating ERK and Wnt pathways through GNB2 regulation.

## Contribution

The paper proposed a novel mechanism involving CCAT2 and GNB2 in colorectal cancer progression.

## Key findings

- CCAT2 was reported to promote cancer cell proliferation and metastasis.
- ERK and Wnt signaling pathways were said to be activated via GNB2 regulation by CCAT2.

## Abstract

RETRACTION: J. Tian, X. Cao, Z. Jiang, J. Wang, W. Fan, S. Zhang, S. Zhao, and J. Sun, “LncRNA CCAT2 Promotes the Proliferation and Metastasis of Colorectal Cancer Through Activation of the ERK and Wnt Signaling Pathways by Regulating GNB2 Expression,” Cancer Medicine 13, no. 17 (2024): e70169, https://doi.org/10.1002/cam4.70169.

The above article, published online on 03 September 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor‐in‐Chief, Stephen Tait; and John Wiley & Sons Ltd. The authors reported to the journal that a third party had detected multiple overlapping panels within and between Figures 2 and 7 in this article. The authors further stated that, upon reviewing the published article, they discovered multiple issues related to image overlap and redundancy. All parties agree that the overlapping and duplicated images constitute a major error in the article and it must be retracted.

## Linked entities

- **Genes:** CCAT2 (colon cancer associated transcript 2) [NCBI Gene 101805488], GNB2 (G protein subunit beta 2) [NCBI Gene 2783]
- **Diseases:** colorectal cancer (MONDO:0005575)

## Full-text entities

- **Genes:** GNB2 (G protein subunit beta 2) [NCBI Gene 2783] {aka HG2C1, NEDHYDF, SSS4, SSS4; NEDHYDF}, CCAT2 (colon cancer associated transcript 2) [NCBI Gene 101805488] {aka LINC00873, NCCP1}, MAPK1 (mitogen-activated protein kinase 1) [NCBI Gene 5594] {aka ERK, ERK-2, ERK2, ERT1, MAPK2, NS13}
- **Diseases:** Colorectal Cancer (MESH:D015179), Metastasis of (MESH:D009362), Cancer (MESH:D009369)

## Full text

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Source: https://tomesphere.com/paper/PMC11803409